Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 14/20 | 0.51 |
| ▸ | CDK2 | P24941 | 14/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 11/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 7/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 2/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22022251 | 0.79 | CDK2 (0.72) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL27573678 | 0.78 | CDK2 (0.58) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL3696802 | 0.76 | CDK1 (0.75) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL3646114 | 0.74 | MEN1 (0.42) | CDK2CDK5MAPTCCNE1 | |
| SCHEMBL25299779 | 0.71 | CDK1 (0.62) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL27560716 | 0.71 | CDK1 (0.51) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL14964230 | 0.71 | CDK2 (0.59) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL14964239 | 0.71 | DYRK1A (0.54) | CCNA2CDK2CCNA1CDK5CDK5R1 | |
| SCHEMBL21019389 | 0.69 | KDM4E (0.50) | MAPTMAPK1TDP1HTT | |
| SCHEMBL29326802 | 0.69 | CDK2 (0.56) | CCNA2CDK2CCNA1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2187889-B1 | USE OF PURINE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT | CENTRE NAT RECH SCIENT (FR) | 2013-11-06 | — | — | EP | disclosed |
| EP-2187889-A2 | USE OF PURINE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT | Centre National De La Recherche Scientifique (FR) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009068761-A2 | USE OF PURINE DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-06-04 | — | — | WO | disclosed |