Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.85 |
| ▸ | GLA | P06280 | 3/20 | 0.85 |
| ▸ | RECQL | P46063 | 2/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.85 |
| ▸ | MEN1 | O00255 | 2/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.84 |
| ▸ | RAB9A | P51151 | 2/20 | 0.84 |
| ▸ | BLM | P54132 | 2/20 | 0.84 |
| ▸ | POLB | P06746 | 1/20 | 0.84 |
| ▸ | MAPT | P10636 | 1/20 | 0.84 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.79 |
| ▸ | HTT | P42858 | 2/20 | 0.79 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.79 |
| ▸ | ACHE | P22303 | 1/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.79 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.79 |
| ▸ | TP53 | P04637 | 2/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1006662 | 1.00 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL1062768 | 0.92 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27502037 | 0.92 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL3847426 | 0.92 | TOP1 (0.85) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL29664993 | 0.92 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL23270615 | 0.92 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL1301708 | 0.92 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27489142 | 0.92 | TOP1 (0.85) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL6848647 | 0.91 | TOP1 (0.84) | TOP1ALDH1A1GLARECQLTDP1 | |
| 9-Aminocamptothecin SCHEMBL26578 | 0.91 | TOP1 (1.00) | TOP1ALDH1A1GLARECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103289461-B | Camptothecin analogues is as the application of anti-fouling agent | XIAMEN UNIVERSITY (CN) | 2016-05-04 | — | — | CN | claimed |
| CN-102159250-B | Multi-arm polymeric alkanoate conjugates | NEKTAR THERAPEUTICS | 2014-08-06 | — | — | CN | disclosed |
| CN-101583380-B | Method for preparing a polymer conjugate | NEKTAR THERAPEUTICS AL CORP | 2013-07-10 | — | — | CN | disclosed |
| CN-102172405-A | Multi-arm polymer prodrugs | NEKTAR THERAPEUTICS | 2011-09-07 | — | — | CN | disclosed |
| CN-102164617-A | Compositions and methods for achieving sustained therapeutic drug concentrations in a subject | NEKTAR THERAPEUTICS | 2011-08-24 | — | — | CN | disclosed |
| CN-102159250-A | Multi-arm polymeric alkanoate conjugates | NEKTAR THERAPEUTICS | 2011-08-17 | — | — | CN | disclosed |
| CN-1852740-B | Prodrugs of highly branched polymers | NEKTAR THERAPEUTICS AL CORP | 2011-05-11 | — | — | CN | disclosed |
| CN-101583380-A | Method for preparing a polymer conjugate | NEKTAR THERAPEUTICS AL CORP (US) | 2009-11-18 | — | — | CN | disclosed |
| CN-1852740-A | Prodrugs of highly branched polymers | NEKTAR THERAPEUTICS AL CORP (US) | 2006-10-25 | — | — | CN | disclosed |
| CN-1720994-A | Treatment of refractory human tumors with epidermal growth factor receptor antagonists | IMCLONE SYSTEMS INC (US) | 2006-01-18 | — | — | CN | disclosed |
| CN-1200734-C | Treatment of refractory human tumors with epidermal growth factor antagonists | IMCLONE SYSTEMS INC (US) | 2005-05-11 | — | — | CN | disclosed |
| CN-1361700-A | Treatment of refractory human tumors with epidermal growth factor antagonists | IMCLONE SYSTEMS INC (US) | 2002-07-31 | — | — | CN | disclosed |