Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.84 |
| ▸ | GLA | P06280 | 3/20 | 0.84 |
| ▸ | RECQL | P46063 | 2/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.84 |
| ▸ | MEN1 | O00255 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.82 |
| ▸ | RAB9A | P51151 | 2/20 | 0.82 |
| ▸ | BLM | P54132 | 2/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.78 |
| ▸ | ACHE | P22303 | 1/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.78 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.78 |
| ▸ | TP53 | P04637 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27489142 | 1.00 | TOP1 (0.85) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27864931 | 0.95 | TOP1 (0.82) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL8204358 | 0.94 | TOP1 (0.81) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27363066 | 0.94 | TOP1 (0.81) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL8490531 | 0.94 | TOP1 (0.81) | TOP1ALDH1A1GLARECQLTDP1 | |
| Hydrochloric Acid SCHEMBL27363068 | 0.93 | TOP1 (0.80) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27479559 | 0.93 | TOP1 (0.80) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL5324470 | 0.93 | TOP1 (0.79) | TOP1ALDH1A1GLARECQLTDP1 | |
| Karenitecin SCHEMBL29537807 | 0.93 | TOP1 (0.79) | TOP1ALDH1A1GLARECQLTDP1 | |
| SCHEMBL27625556 | 0.93 | TOP1 (0.79) | TOP1ALDH1A1GLARECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1159192-A | Substituted camptothecin derivatives and process for their preparation | PHARMACIA & UPJOHN SPA (IT) | 1997-09-10 | — | — | CN | claimed |
| EP-2042194-A2 | Treatment of refractory human tumors with epidermal growth factor receptor antagonists | IMCLONE SYSTEMS, INC. (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20050112120-A1 | Treatment of refractory human tumors with epidermal growth factor receptor antagonists | IMCLONE LLC | 2005-05-26 | — | — | US | disclosed |
| EP-1218032-A4 | TREATMENT OF REFRACTORY HUMAN TUMORS WITH EPIDERMAL GROWTH FACTOR RECEPTOR ANTAGONISTS | IMCLONE SYSTEMS INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-20030202973-A1 | Treatment of refractory human tumors with epidermal growth factor receptor and HER1 mitogenic ligand (EGFRML) antagonists | DR. GEORGE PIECZENIK (US) | 2003-10-30 | — | — | US | disclosed |
| US-20030157104-A1 | Treatment of refractory human tumors with epidermal growth factor receptor antagonists | WAKSAL HARLAN W (US) | 2003-08-21 | — | — | US | disclosed |
| EP-1218032-A1 | TREATMENT OF REFRACTORY HUMAN TUMORS WITH EPIDERMAL GROWTH FACTOR RECEPTOR ANTAGONISTS | IMCLONE SYSTEMS, INC. (US) | 2002-07-03 | — | — | EP | disclosed |
| US-20020012663-A1 | Treatment of refractory human tumors with epidermal growth factor receptor antagonists | WAKSAL HARLAN W (US) | 2002-01-31 | — | — | US | disclosed |
| WO-2000069459-A1 | TREATMENT OF REFRACTORY HUMAN TUMORS WITH EPIDERMAL GROWTH FACTOR RECEPTOR ANTAGONISTS | IMCLONE SYSTEMS INCORPORATED (US) | 2000-11-23 | — | — | WO | disclosed |
| US-5856333-A | ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-01-05 | — | — | US | disclosed |
| CN-1159192-A | Substituted camptothecin derivatives and process for their preparation | PHARMACIA & UPJOHN SPA (IT) | 1997-09-10 | — | — | CN | disclosed |
| EP-0777670-A1 | SUBSTITUTED CAMPTOTHECIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996037496-A1 | SUBSTITUTED CAMPTOTHECIN DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.P.A. (IT) | 1996-11-28 | — | — | WO | disclosed |