Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.39 |
| ▸ | ESR1 | P03372 | 5/20 | 0.39 |
| ▸ | PON1 | P27169 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
| ▸ | GALNT2 | Q10471 | 1/20 | 0.32 |
| ▸ | GALNT1 | Q10472 | 1/20 | 0.32 |
| ▸ | GALNT3 | Q14435 | 1/20 | 0.32 |
| ▸ | GALNT10 | Q86SR1 | 1/20 | 0.32 |
| ▸ | GALNT13 | Q8IUC8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980111 | 0.95 | ELANE (0.42) | ELANEESR2ESR1PON1MAOB | |
| SCHEMBL2707244 | 0.88 | NR1I2 (0.41) | ESR2ESR1PON1NR1I2CSNK2A1 | |
| SCHEMBL9980108 | 0.83 | CYP1A2 (0.37) | ELANEPON1MAOBCYP1A2CYP2A6 | |
| SCHEMBL16622744 | 0.83 | ELANE (0.45) | ELANEESR2ESR1CYP1A2CYP2A6 | |
| SCHEMBL2756601 | 0.80 | NR1I2 (0.35) | ELANEPON1MAOBCYP1A2CYP2A6 | |
| SCHEMBL14985659 | 0.80 | ELANE (0.45) | ELANEESR2ESR1 | |
| SCHEMBL18462386 | 0.80 | TBK1 (0.36) | ESR2ESR1PON1NR1I2CSNK2A1 | |
| SCHEMBL2757171 | 0.79 | ELANE (0.41) | ELANEPON1MAOBCYP1A2CYP2A6 | |
| SCHEMBL2757167 | 0.76 | MAOB (0.39) | ELANEESR2ESR1PON1MAOB | |
| SCHEMBL9980104 | 0.76 | ELANE (0.41) | ELANEPON1MAOBPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120264711-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20120157404-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-8088368-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20100310512-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. | 2010-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264711-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | ELANE 1237/4885ESR2 4021/4885ESR1 4094/4885 |
| US-20120157404-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | ELANE 1237/4885ESR2 4021/4885ESR1 4094/4885 |
| US-20100310512-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | ELANE 1237/4885ESR2 4021/4885ESR1 4094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.