Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 11/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | GRK6 | P43250 | 2/20 | 0.45 |
| ▸ | ULK1 | O75385 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045486 | 0.86 | SLC2A1 (0.53) | BCHEACHEAPPNTRK1NTRK3 | |
| SCHEMBL2204246 | 0.85 | ULK1 (0.57) | NTRK1ULK1 | |
| SCHEMBL2204494 | 0.85 | ULK1 (0.51) | NTRK1GRK6ULK1 | |
| SCHEMBL2203633 | 0.85 | NTRK1 (0.49) | BCHEACHEAPPNTRK1NTRK3 | |
| SCHEMBL2202078 | 0.85 | ULK1 (0.52) | NTRK1GRK6ULK1 | |
| SCHEMBL2205064 | 0.84 | NTRK1 (0.46) | BCHEACHEAPPNTRK1NTRK3 | |
| SCHEMBL27577367 | 0.84 | NTRK1 (0.48) | NTRK1NTRK3NTRK2 | |
| SCHEMBL6917206 | 0.84 | ULK1 (0.49) | NTRK1NTRK3NTRK2GRK6ULK1 | |
| SCHEMBL2203233 | 0.84 | NTRK1 (0.46) | APPNTRK1NTRK3NTRK2GRK6 | |
| SCHEMBL2206518 | 0.84 | NTRK1 (0.51) | BCHEACHEAPPNTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100340555-C | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2007-10-03 | — | — | CN | claimed |
| CN-1486312-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-03-31 | — | — | CN | claimed |
| CN-102250071-A | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA | 2011-11-23 | — | — | CN | disclosed |
| CN-100408573-C | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2008-08-06 | — | — | CN | disclosed |
| CN-100406454-C | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2008-07-30 | — | — | CN | disclosed |
| CN-100340555-C | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2007-10-03 | — | — | CN | disclosed |
| CN-1549812-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-11-24 | — | — | CN | disclosed |
| CN-1487933-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-04-07 | — | — | CN | disclosed |
| CN-1486312-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-03-31 | — | — | CN | disclosed |
| CN-1486311-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-03-31 | — | — | CN | disclosed |
| CN-1486310-A | Pyrazole compounds useful as protein kinase inhibitors | ��̩��˹ҩ��ɷ�����˾ | 2004-03-31 | — | — | CN | disclosed |