Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 9/20 | 0.53 |
| ▸ | ACHE | P22303 | 8/20 | 0.53 |
| ▸ | BCHE | P06276 | 6/20 | 0.53 |
| ▸ | GRK6 | P43250 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203633 | 0.94 | NTRK1 (0.49) | SLC2A1APPACHEBCHEGRK6 | |
| Benzene SCHEMBL27577366 | 0.86 | BCHE (0.52) | APPACHEBCHEGRK6NTRK1 | |
| SCHEMBL2206518 | 0.85 | NTRK1 (0.51) | APPACHEBCHENTRK1IGF1R | |
| SCHEMBL2203233 | 0.85 | NTRK1 (0.46) | SLC2A1APPGRK6AURKANTRK1 | |
| SCHEMBL2205064 | 0.85 | NTRK1 (0.46) | APPACHEBCHEGRK6AURKA | |
| SCHEMBL2204246 | 0.83 | ULK1 (0.57) | AURKANTRK1 | |
| SCHEMBL2200909 | 0.82 | ULK1 (0.51) | SLC2A1AURKANTRK1KDM4EALDH1A1 | |
| SCHEMBL2204494 | 0.82 | ULK1 (0.51) | GRK6AURKANTRK1 | |
| SCHEMBL11340376 | 0.82 | IGF1R (0.70) | NTRK1IGF1R | |
| SCHEMBL12430677 | 0.82 | NTRK1 (0.75) | GRK6AURKANTRK1IGF1RNTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345925-B1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2006-05-17 | — | — | EP | claimed |