Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | CDC25B | P30305 | 8/20 | 0.42 |
| ▸ | AOC2 | O75106 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | CDC25C | P30307 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27582049 | 0.85 | AKR1C3 (0.53) | CDC25BAKR1C3AKR1C2CDC25ACDC25C | |
| SCHEMBL27561547 | 0.75 | RAPGEF4 (0.51) | ALDH1A1MEN1KMT2AEGFR | |
| SCHEMBL8856711 | 0.75 | ALDH1A1 (0.58) | KDM4EALDH1A1SIRT2CDC25BAOC2 | |
| SCHEMBL27561396 | 0.74 | ABCG2 (0.44) | ALDH1A1SIRT2 | |
| SCHEMBL21792030 | 0.73 | ALDH1A1 (0.59) | KDM4EALDH1A1AOC2KCNK3KCNK9 | |
| SCHEMBL3055037 | 0.72 | ALDH1A1 (0.63) | KDM4EALDH1A1AOC2KCNK3KCNK9 | |
| SCHEMBL27561508 | 0.72 | POLB (0.47) | ALDH1A1 | |
| SCHEMBL27576859 | 0.72 | TNNI3K (0.45) | ALDH1A1EGFR | |
| SCHEMBL24934249 | 0.71 | ALDH1A1 (0.61) | KDM4EALDH1A1AOC2KCNK3KCNK9 | |
| SCHEMBL29398556 | 0.71 | ALDH1A1 (0.69) | KDM4EALDH1A1AOC2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | claimed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | disclosed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |