Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 5/20 | 0.43 |
| ▸ | RBPJ | Q06330 | 3/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27567973 | 0.94 | NOTCH1 (0.42) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL27567966 | 0.92 | HDAC3 (0.41) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL27570564 | 0.89 | NOTCH1 (0.40) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL27577826 | 0.86 | NOTCH1 (0.48) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL27567906 | 0.86 | KCNH2 (0.41) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL28747942 | 0.85 | PSEN1 (0.43) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL28750577 | 0.85 | NOTCH1 (0.37) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL27567874 | 0.81 | NOTCH1 (0.39) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL27587101 | 0.78 | OPRK1 (0.41) | NOTCH1RBPJHDAC1GABRPGABRD | |
| SCHEMBL27509418 | 0.77 | HDAC3 (0.50) | HDAC3HDAC1HDAC6HDAC8HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1399634-A | Hydroxyalkanoyl aminolactams and related structure as inhibitors of A beta protein production | BRISTOL MYERS SQUIBB PHARMA IN (US) | 2003-02-26 | — | — | CN | disclosed |