Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 3/20 | 0.42 |
| ▸ | RBPJ | Q06330 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.42 |
| ▸ | GABRE | P78334 | 1/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27567966 | 0.95 | HDAC3 (0.41) | NOTCH1RBPJGABRPGABRDGABRA1 | |
| SCHEMBL27587181 | 0.94 | NOTCH1 (0.43) | NOTCH1RBPJGABRPGABRDGABRA1 | |
| SCHEMBL27570564 | 0.92 | NOTCH1 (0.40) | NOTCH1RBPJGABRPGABRDGABRA1 | |
| SCHEMBL27567906 | 0.89 | KCNH2 (0.41) | NOTCH1RBPJGABRPGABRDGABRA1 | |
| SCHEMBL28747942 | 0.88 | PSEN1 (0.43) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL28750577 | 0.88 | NOTCH1 (0.37) | NOTCH1RBPJGABRPGABRDGABRA1 | |
| SCHEMBL27577826 | 0.88 | NOTCH1 (0.48) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL27567874 | 0.86 | NOTCH1 (0.39) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL27587101 | 0.81 | OPRK1 (0.41) | NOTCH1RBPJGABRPGABRDGABRA1 | |
| SCHEMBL27567902 | 0.80 | CCKBR (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1399634-A | Hydroxyalkanoyl aminolactams and related structure as inhibitors of A beta protein production | BRISTOL MYERS SQUIBB PHARMA IN (US) | 2003-02-26 | — | — | CN | disclosed |