Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | CCR8 | P51685 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925761 | 0.78 | CCR1 (0.50) | HPGDSGLO1SLC40A1CCR1CCR8 | |
| SCHEMBL20306596 | 0.78 | PKM (0.49) | HPGDSGLO1MEN1KMT2ASLC40A1 | |
| SCHEMBL1994732 | 0.75 | CCR1 (0.57) | HPGDSGLO1MEN1KMT2ASLC40A1 | |
| SCHEMBL30492680 | 0.75 | CCR1 (0.57) | HPGDSGLO1MEN1KMT2ASLC40A1 | |
| SCHEMBL662676 | 0.74 | KDM4E (0.47) | MEN1KMT2ACCR1CCR8HTT | |
| SCHEMBL2582442 | 0.73 | CCR1 (0.46) | MEN1KMT2ASLC40A1CCR1CCR8 | |
| SCHEMBL31276857 | 0.73 | CCR1 (0.46) | MEN1KMT2ASLC40A1CCR1CCR8 | |
| SCHEMBL4025285 | 0.72 | PDE4A (0.39) | MEN1KMT2ACCR1CCR8HTT | |
| Water SCHEMBL28285432 | 0.72 | LMNA (0.61) | MEN1KMT2ACCR1CCR8HTT | |
| SCHEMBL15007502 | 0.72 | KDM4E (0.48) | MEN1KMT2ACCR1CCR8HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100508978-C | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors | MERCK & CO INC MERCK FROSST CA (US) | 2009-07-08 | — | — | CN | disclosed |
| CN-1551769-A | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors | — | 2004-12-01 | — | — | CN | disclosed |