Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | PRKCI | P41743 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13903470 | 0.73 | KDM5A (0.46) | KDM5AKDM4CLRRK2DAODYRK1A | |
| SCHEMBL28380264 | 0.72 | MAPK1 (0.48) | KDM5AKDM4CLRRK2DAODYRK1A | |
| SCHEMBL16593421 | 0.72 | KDM5A (0.45) | KDM5AKDM4CLRRK2DAODYRK1A | |
| SCHEMBL13909686 | 0.71 | KDM5A (0.45) | KDM5AKDM4CLRRK2DAODYRK1A | |
| SCHEMBL27595634 | 0.70 | KDM5A (0.47) | KDM5AKDM4CLRRK2DAODYRK1A | |
| SCHEMBL17128283 | 0.70 | KDM5A (0.44) | KDM5AKDM4CLRRK2DAODYRK1A | |
| SCHEMBL6733348 | 0.70 | KDM4C (0.69) | KDM5AKDM4CDAOKDM4EALDH1A1 | |
| SCHEMBL21042568 | 0.69 | KDM5A (0.54) | KDM5AKDM4CLRRK2DAOAXL | |
| SCHEMBL13903471 | 0.69 | ALDH1A1 (0.54) | KDM5AKDM4CDAODYRK1AKDM4E | |
| SCHEMBL1472608 | 0.68 | KDM5A (0.56) | KDM5AKDM4CLRRK2DAODYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101229164-B | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives | BRISTOL MYERS SQUIBB CO | 2013-01-02 | — | — | CN | disclosed |
| CN-100384423-C | Compositions and antiviral activity of substituted azaindoloxoacetylpiperazine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2008-04-30 | — | — | CN | disclosed |
| CN-100379421-C | Compositions and antiviral activity of substituted azaindoloxoacetylpiperazine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2008-04-09 | — | — | CN | disclosed |
| CN-1688311-A | Compositions and antiviral activity of substituted azaindoloxoacetylpiperazine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2005-10-26 | — | — | CN | disclosed |
| CN-1612763-A | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2005-05-04 | — | — | CN | disclosed |