Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596141 | 0.87 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27614917 | 0.85 | F2 (0.37) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL27596187 | 0.77 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11LCK | |
| SCHEMBL5564692 | 0.77 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL27614922 | 0.74 | MAPK13 (0.48) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5568018 | 0.73 | NPY5R (0.48) | CYP2C9CYP2C19 | |
| SCHEMBL5564465 | 0.73 | NPY5R (0.51) | CYP2C9CYP2C19 | |
| SCHEMBL4429774 | 0.73 | CCR8 (0.35) | MAPK14MAPK13MAPK12MAPK11LCK | |
| SCHEMBL27614995 | 0.72 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11NPC1 | |
| SCHEMBL5564038 | 0.71 | MAPT (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | claimed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | claimed |
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |