Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27596181 | 0.87 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596142 | 0.85 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27596187 | 0.77 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5564692 | 0.76 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5565210 | 0.74 | KMT2A (0.45) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4428635 | 0.73 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5560029 | 0.73 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5568929 | 0.72 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5396650 | 0.72 | MAPK13 (0.50) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5560947 | 0.71 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | claimed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | claimed |
| CN-100363362-C | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | CN | disclosed |
| CN-1639158-A | Thiazole derivatives as NPY receptor antagonists | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |