Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.42 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.40 |
| ▸ | PTGFR | P43088 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27597154 | 0.91 | WNT3A (0.46) | ABL1IGF2BP2DHODHWNT3A | |
| SCHEMBL5557201 | 0.90 | ABL1 (0.39) | ABL1IGF2BP2DHODHPTGFRWNT3A | |
| SCHEMBL27615837 | 0.85 | ALDH1A1 (0.53) | POLB | |
| SCHEMBL27597149 | 0.82 | SERPINE1 (0.43) | ERCC5FEN1POLB | |
| SCHEMBL27597180 | 0.82 | ABL1 (0.42) | ABL1IGF2BP2DHODHWNT3A | |
| SCHEMBL5557484 | 0.81 | WNT3A (0.43) | ABL1WNT3A | |
| SCHEMBL27597176 | 0.80 | POLB (0.46) | ERCC5FEN1POLB | |
| SCHEMBL27615941 | 0.80 | POLB (0.46) | ERCC5FEN1POLB | |
| SCHEMBL27615918 | 0.80 | ALDH1A1 (0.46) | ABL1ERCC5FEN1POLB | |
| SCHEMBL27597160 | 0.80 | ALDH1A1 (0.46) | ABL1ERCC5FEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497333-C | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| CN-1633430-A | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2005-06-29 | — | — | CN | disclosed |