Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27599735 | 0.83 | KCNA5 (0.49) | KCNA5SLC6A2SLC6A4KCNH2USP2 | |
| SCHEMBL27599691 | 0.78 | GPR119 (0.52) | KCNA5 | |
| SCHEMBL1474674 | 0.77 | CHRM1 (0.48) | KCNA5SLC6A2SLC6A4KCNH2USP2 | |
| SCHEMBL27599455 | 0.72 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27618100 | 0.71 | KCNA5 (0.41) | KCNA5SLC6A2SLC6A4KCNH2USP2 | |
| SCHEMBL5018831 | 0.70 | KCNA5 (0.68) | KCNA5KCNH2ALDH1A1CYP1A2ADRA2A | |
| SCHEMBL22190043 | 0.70 | KCNA5 (0.63) | KCNA5KCNH2CYP1A2HIF1AHSD17B10 | |
| SCHEMBL22190042 | 0.70 | KCNA5 (0.63) | KCNA5KCNH2CYP1A2HIF1AHSD17B10 | |
| SCHEMBL4138380 | 0.69 | CHRNB2 (0.54) | KCNA5SLC6A2SLC6A4KCNH2CHRM1 | |
| SCHEMBL27617861 | 0.69 | SLC6A2 (0.50) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100389113-C | Nitrogen-containing heterocyclic compound and drug containing same | EISAI CO LTD (JP) | 2008-05-21 | — | — | CN | disclosed |
| CN-1630650-A | Nitrogen-containing heterocyclic compound and drug containing same | EISAI CO LTD (JP) | 2005-06-22 | — | — | CN | disclosed |