Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.42 |
| ▸ | NOS1 | P29475 | 5/20 | 0.40 |
| ▸ | NOS2 | P35228 | 4/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYBB | P04839 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27600750 | 0.82 | BACE1 (0.39) | BACE1NOS1NOS2APPNOS3 | |
| SCHEMBL27633950 | 0.79 | SMN1; SMN2 (0.42) | NOS1NOS2NOS3KCNH2KDM4E | |
| SCHEMBL28065632 | 0.79 | CCR1 (0.34) | KCNH2 | |
| SCHEMBL27777588 | 0.79 | HTR7 (0.35) | KCNH2 | |
| SCHEMBL27927802 | 0.76 | BRD4 (0.37) | KDM4E | |
| SCHEMBL28255460 | 0.75 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL27680513 | 0.75 | BACE1 (0.43) | BACE1NOS1NOS2APPITGB1 | |
| SCHEMBL5252807 | 0.71 | HRH1 (0.50) | KDM4E | |
| SCHEMBL6014618 | 0.71 | NOS1 (0.48) | BACE1NOS1NOS2APPNOS3 | |
| SCHEMBL7980764 | 0.71 | NOS1 (0.48) | BACE1NOS1NOS2APPNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102083438-B | The quinoline of conditioning agent and related analogs as silent message regulatory factor | 西特里斯药业公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105198872-A | Chromenone analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2015-12-30 | — | — | CN | disclosed |
| CN-102227417-B | Chromenone analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS, INC. (US) | 2015-09-16 | — | — | CN | disclosed |
| CN-102227420-B | Quinazolinone, quinolone and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2015-06-24 | — | — | CN | disclosed |
| CN-104193740-A | BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS INC | 2014-12-10 | — | — | CN | disclosed |
| CN-102143957-B | Benzimidazoles and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2014-08-20 | — | — | CN | disclosed |
| CN-102143957-A | Benzimidazoles and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2011-08-03 | — | — | CN | disclosed |
| CN-102112475-A | Imidazopyridine and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2011-06-29 | — | — | CN | disclosed |
| CN-102083438-A | Quenolines and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2011-06-01 | — | — | CN | disclosed |
| CN-1478077-A | Benzamide compounds as APO B secretion inhibitors | ����ҩƷ��ҵ��ʽ���� | 2004-02-25 | — | — | CN | disclosed |