Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32669042 | 0.82 | — | — | |
| Ethylene Glycol SCHEMBL3829138 | 0.78 | TSHR (0.42) | HSD17B10CA2CA9TSHR | |
| SCHEMBL76625 | 0.77 | — | — | |
| SCHEMBL18480663 | 0.77 | — | — | |
| Propylene Glycol SCHEMBL278652 | 0.76 | TDP1 (0.50) | TDP1HSD17B10LMNACA2CA9 | |
| SCHEMBL13909999 | 0.76 | USP2 (0.47) | HSD17B10USP2LMNACYP3A4MAPT | |
| Propylene Glycol SCHEMBL27600898 | 0.76 | TDP1 (0.43) | TDP1HSD17B10TSHR | |
| Di(Hydroxyethyl)Ether SCHEMBL10943449 | 0.75 | TSHR (0.56) | HSD17B10MAPTCA2CA9TSHR | |
| SCHEMBL2470456 | 0.75 | — | — | |
| Propylene Glycol SCHEMBL27443040 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104583149-A | Cement composition additive comprising cross-linked polycarboxylic acid-based copolymer, and cement composition comprising same | LG CHEMICAL LTD | 2015-04-29 | — | — | CN | claimed |
| CN-104487399-A | Additive for cement composition comprising polycarboxylic acid copolymer and cement composition comprising same | LG CHEMICAL LTD | 2015-04-01 | — | — | CN | claimed |
| CN-100519465-C | Cement admixture having excellent water-reducing ability and method for preparing the same | LG CHEMICAL LTD (KR) | 2009-07-29 | — | — | CN | claimed |
| CN-1522233-A | Cement admixture having superior water-reducing properties and method for preparing the same | LG��ѧ��ʽ���� | 2004-08-18 | — | — | CN | claimed |
| CN-104583149-A | Cement composition additive comprising cross-linked polycarboxylic acid-based copolymer, and cement composition comprising same | LG CHEMICAL LTD | 2015-04-29 | — | — | CN | disclosed |
| CN-104487399-A | Additive for cement composition comprising polycarboxylic acid copolymer and cement composition comprising same | LG CHEMICAL LTD | 2015-04-01 | — | — | CN | disclosed |
| CN-100519465-C | Cement admixture having excellent water-reducing ability and method for preparing the same | LG CHEMICAL LTD (KR) | 2009-07-29 | — | — | CN | disclosed |
| CN-1522233-A | Cement admixture having superior water-reducing properties and method for preparing the same | LG��ѧ��ʽ���� | 2004-08-18 | — | — | CN | disclosed |