Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5953263 | 0.90 | MEN1 (0.44) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9963878 | 0.83 | CYP2D6 (0.50) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13239697 | 0.83 | ALDH1A1 (0.48) | MEN1KMT2AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL21750427 | 0.81 | HRH2 (0.46) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21413024 | 0.81 | MEN1 (0.46) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13239699 | 0.81 | KDM4E (0.49) | ALDH1A1SMN1; SMN2KDM4ESIGMAR1POLB | |
| SCHEMBL12989425 | 0.80 | SIGMAR1 (0.42) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL24562861 | 0.79 | MEN1 (0.50) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12422451 | 0.79 | HRH3 (0.46) | ALDH1A1KDM4EGAAHRH3 | |
| SCHEMBL12422452 | 0.79 | HRH3 (0.46) | ALDH1A1KDM4EGAAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110016026-A | A kind of pyrimido pyridine compounds, preparation method and purposes with anti-tumor activity | 如东凌达生物医药科技有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-109608443-A | Heterocycleamide as protein modulator | 葛兰素史密斯克莱知识产权发展有限公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-109563092-A | It can be used as the 2- phenylimidazole of the active inhibitor of mammal tyrosine kinase ROR1 simultaneously [4,5-B] pyridine -7- amine derivative | 坎塞拉有限公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-109071514-A | Heterocyclic amides as protein modulators | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-101607958-A | Quinazoline compound | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | CN | disclosed |
| CN-1625555-A | Quinazoline compounds | ASTRAZENECA AB (SE) | 2005-06-08 | — | — | CN | disclosed |