Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059362 | 0.80 | ATM (0.66) | KMT2AATML3MBTL1NAMPTPIK3CD | |
| SCHEMBL2708828 | 0.78 | ATM (0.55) | KMT2AATML3MBTL1NAMPTPIK3CD | |
| SCHEMBL17203603 | 0.75 | ATM (0.77) | KMT2AATML3MBTL1NAMPTPIK3CD | |
| SCHEMBL14509638 | 0.75 | ATM (0.77) | KMT2AATML3MBTL1NAMPTPIK3CD | |
| SCHEMBL5250912 | 0.73 | ATM (0.75) | KMT2AATML3MBTL1NAMPTDRD2 | |
| SCHEMBL6034582 | 0.72 | ATM (0.97) | KMT2AATML3MBTL1NAMPTPIK3CD | |
| SCHEMBL10496019 | 0.72 | ATM (0.76) | KMT2AATML3MBTL1NAMPTPIK3CD | |
| SCHEMBL26027930 | 0.71 | POLB (0.51) | KMT2AL3MBTL1TSHRMEN1KDM4E | |
| SCHEMBL28239056 | 0.71 | KMT2A (0.55) | KMT2AATML3MBTL1NAMPTTSHR | |
| SCHEMBL11609367 | 0.70 | DRD2 (0.59) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100519550-C | 2-oxoindole compounds having inhibitory activity on glycogen synthase kinase 3 receptor | ASTRAZENECA AB SE (SE) | 2009-07-29 | — | — | CN | disclosed |
| CN-1923812-A | New compounds | ASTRAZENECA AB (SE) | 2007-03-07 | — | — | CN | disclosed |
| CN-1642938-A | Novel compounds | ASTRAZENECA AB (SE) | 2005-07-20 | — | — | CN | disclosed |