Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10464592 | 0.82 | MAPT (0.47) | MAPTTP53SMN1; SMN2LMNATSHR | |
| SCHEMBL13394268 | 0.79 | TP53 (0.70) | MAPTTP53SMN1; SMN2LMNATSHR | |
| SCHEMBL31732235 | 0.79 | LMNA (0.49) | MAPTTP53SMN1; SMN2LMNATSHR | |
| SCHEMBL3592857 | 0.74 | MAPT (0.42) | MAPTTP53SMN1; SMN2PARP15PARP10 | |
| SCHEMBL3591179 | 0.74 | MAPT (0.44) | MAPTTP53SMN1; SMN2LMNATSHR | |
| SCHEMBL17621008 | 0.74 | THRB (0.44) | MAPTTP53SMN1; SMN2THRB | |
| SCHEMBL27706618 | 0.74 | MAPT (0.42) | MAPTTP53SMN1; SMN2LMNATSHR | |
| SCHEMBL13394267 | 0.74 | MAPT (0.78) | MAPTTP53SMN1; SMN2LMNATSHR | |
| SCHEMBL3588711 | 0.73 | MAPT (0.52) | MAPTTP53SMN1; SMN2LMNARAB9A | |
| SCHEMBL17129983 | 0.72 | MAPT (0.69) | MAPTTP53SMN1; SMN2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100506825-C | Heterotricyclyl 6-alkylidene-penems as beta epsilontaualpha-lactamase inhibitors | WYETH CORP (US) | 2009-07-01 | — | — | CN | disclosed |
| CN-1649882-A | Heterotricyclyl 6-alkylidene-penems as beta epsilontaualpha-lactamase inhibitors | WYETH CORP (US) | 2005-08-03 | — | — | CN | disclosed |