⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184239 | 0.78 | ADRA2A (0.39) | — | |
| SCHEMBL14480428 | 0.78 | ADRA2A (0.39) | — | |
| SCHEMBL2760888 | 0.78 | ADRA2A (0.39) | — | |
| Hydrochloric Acid SCHEMBL1440350 | 0.76 | ADRA2A (0.41) | — | |
| SCHEMBL20140862 | 0.76 | KMT2A (0.40) | — | |
| Hydrochloric Acid SCHEMBL1440719 | 0.76 | ADRA2A (0.41) | — | |
| Hydrochloric Acid SCHEMBL1440347 | 0.76 | ADRA2A (0.41) | — | |
| SCHEMBL996985 | 0.72 | ADRB2 (0.37) | — | |
| SCHEMBL441306 | 0.72 | ADRB2 (0.37) | — | |
| SCHEMBL1000434 | 0.72 | ADRB2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150266822-A1 | Amide Compounds, Compositions And Uses Thereof | RENOVIS, INC. | 2015-09-24 | — | — | US | claimed |
| US-20150266822-A1 | Amide Compounds, Compositions And Uses Thereof | RENOVIS, INC. | 2015-09-24 | — | — | US | disclosed |
| US-8946439-B2 | Amide compounds, compositions and uses thereof | EVOTEC AG (DE) | 2015-02-03 | — | — | US | disclosed |
| EP-2262766-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009110985-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2009-09-11 | — | — | WO | disclosed |