Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 14/20 | 0.46 |
| ▸ | P2RX2 | Q9UBL9 | 13/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760946 | 1.00 | P2RX3 (0.46) | P2RX3P2RX2P2RX7NR1I2TP53 | |
| SCHEMBL2760840 | 0.92 | P2RX7 (0.45) | P2RX3P2RX2P2RX7NR1I2TP53 | |
| SCHEMBL2760841 | 0.92 | P2RX7 (0.45) | P2RX3P2RX2P2RX7NR1I2TP53 | |
| SCHEMBL2760721 | 0.89 | P2RX3 (0.49) | P2RX3P2RX2P2RX7TP53MAPT | |
| SCHEMBL2760722 | 0.89 | P2RX3 (0.49) | P2RX3P2RX2P2RX7TP53MAPT | |
| SCHEMBL2761210 | 0.84 | P2RX3 (0.47) | P2RX3P2RX2P2RX7NR1I2NPC1 | |
| SCHEMBL2761211 | 0.84 | P2RX3 (0.47) | P2RX3P2RX2P2RX7NR1I2NPC1 | |
| SCHEMBL1495443 | 0.83 | P2RX3 (0.51) | P2RX3P2RX2NR1I2CYP2C9UGT1A1 | |
| SCHEMBL2760776 | 0.82 | PSEN1 (0.41) | P2RX3P2RX2TP53MAPTNPC1 | |
| SCHEMBL2760777 | 0.82 | PSEN1 (0.41) | P2RX3P2RX2TP53MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262766-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009110985-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2009-09-11 | — | — | WO | disclosed |