Histidine

Histidine

SCHEMBL27610893

CC(C)CC(N)C(=O)O.CCC(C)C(N)C(=O)O.NC(Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.42
SLC1A3 P43003 4/20 0.35
SLC1A2 P43004 4/20 0.35
CYP3A4 P08684 1/20 0.34
SLC1A1 P43005 3/20 0.33
CYP1A2 P05177 1/20 0.33
ANPEP P15144 1/20 0.33
RNPEP Q9H4A4 1/20 0.33
DNPEP Q9ULA0 1/20 0.33
GRIA4 P48058 4/20 0.32
GRIA1 P42261 3/20 0.32
GRIA2 P42262 3/20 0.32
GRIA3 P42263 3/20 0.32
GRIK1 P39086 2/20 0.32
GRIK2 Q13002 2/20 0.32
GRIK3 Q13003 2/20 0.32
GRIK4 Q16099 2/20 0.32
GRIK5 Q16478 2/20 0.32
ACE P12821 1/20 0.31
LARS1 Q9P2J5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL183769 0.94 SLC7A5 (0.38) SLC7A5CYP3A4CYP1A2GRIA4GRIA1
Histidine SCHEMBL183768 0.94 SLC7A5 (0.38) SLC7A5CYP3A4CYP1A2GRIA4GRIA1
Histidine SCHEMBL14940945 0.94 SLC7A5 (0.38) SLC7A5CYP3A4CYP1A2GRIA4GRIA1
Tyrosine SCHEMBL27340798 0.91 SLC7A5 (0.46) SLC7A5ANPEPRNPEPDNPEPACE
Histidine SCHEMBL2024731 0.91 SLC7A5 (0.37) SLC7A5CYP3A4CYP1A2GRIA4GRIA1
Histidine SCHEMBL716109 0.90 SLC7A5 (0.51) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1
Histidine SCHEMBL716108 0.90 SLC7A5 (0.51) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1
Histidine SCHEMBL1537416 0.90 SLC7A5 (0.51) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1
Histidine SCHEMBL5670665 0.90 SLC7A5 (0.34) SLC7A5SLC1A3SLC1A2SLC1A1CYP1A2
Histidine SCHEMBL1528037 0.89 SLC7A5 (0.35) SLC7A5CYP3A4CYP1A2GRIA4GRIA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1671769-B Polyethylene glycol aldehyde derivatives HOFFMANN LA ROCHE 2010-05-12 CN disclosed
CN-1878472-A Protein-rich baked food and process for producing the same BOURBON CORP (JP) 2006-12-13 CN disclosed
CN-1671769-A Polyethylene glycol aldehyde derivatives HOFFMANN LA ROCHE (CH) 2005-09-21 CN disclosed