Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL27716140 | 0.96 | ALOX15 (0.33) | SLC7A5GRM8GRM6GRIN2DGRIN3B | |
| Histidine SCHEMBL8843660 | 0.93 | SLC7A5 (0.33) | SLC7A5GRM8GRM6GRIN2DGRIN3B | |
| Histidine SCHEMBL27673557 | 0.92 | GRIA1 (0.40) | SLC7A5GRM8GRM6GRIN2DGRIN3B | |
| Histidine SCHEMBL28540445 | 0.92 | THRB (0.34) | GSR | |
| Histidine SCHEMBL27610893 | 0.90 | SLC7A5 (0.42) | SLC7A5CYP1A2GRIK1GRIA1GRIA2 | |
| Histidine SCHEMBL1528035 | 0.89 | SLC7A5 (0.35) | SLC7A5CYP1A2GRIK1GRIA1GRIA2 | |
| Histidine SCHEMBL1528037 | 0.89 | SLC7A5 (0.35) | SLC7A5CYP1A2GRIK1GRIA1GRIA2 | |
| Histidine SCHEMBL27580772 | 0.89 | SLC7A5 (0.35) | SLC7A5CYP1A2GRIK1GRIA1GRIA2 | |
| Dl-Phenylalanine SCHEMBL27711798 | 0.88 | ALPI (0.37) | SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Histidine SCHEMBL4859351 | 0.86 | SLC1A3 (0.40) | SLC7A5GRM8GRM6GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702625-A1 | MEDICINE CONTAINING GENETICALLY MODIFIED ANTIBODY AGAINST CHEMOKINE RECEPTOR CCR4 | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |