Histidine

Histidine

SCHEMBL716109

CC(C)C[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 3/20 0.51
SLC1A3 P43003 4/20 0.42
SLC1A2 P43004 4/20 0.42
CYP3A4 P08684 1/20 0.40
CYP1A2 P05177 1/20 0.39
ANPEP P15144 1/20 0.38
RNPEP Q9H4A4 1/20 0.38
DNPEP Q9ULA0 1/20 0.38
GRIA1 P42261 4/20 0.38
GRIA2 P42262 4/20 0.38
GRIA3 P42263 4/20 0.38
GRIA4 P48058 4/20 0.38
SLC1A1 P43005 3/20 0.37
LARS1 Q9P2J5 2/20 0.36
ALPI P09923 1/20 0.36
PKM P14618 1/20 0.36
PTGS1 P23219 1/20 0.36
XIAP P98170 1/20 0.36
GRIK1 P39086 3/20 0.35
GRM2 Q14416 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL1537416 1.00 SLC7A5 (0.51) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Histidine SCHEMBL716108 1.00 SLC7A5 (0.51) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Histidine SCHEMBL28870433 0.99 SLC7A5 (0.50) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Histidine SCHEMBL5072093 0.97 SLC7A5 (0.49) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Histidine SCHEMBL21925063 0.97 SLC7A5 (0.49) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Histidine SCHEMBL21774926 0.95 SLC7A5 (0.46) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Histidine SCHEMBL26967573 0.95 SLC7A5 (0.46) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Histidine SCHEMBL21638967 0.94 SLC7A5 (0.45) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Histidine SCHEMBL245022 0.94 SLC7A5 (0.45) SLC7A5SLC1A3SLC1A2CYP3A4CYP1A2
Phenylalanine SCHEMBL14631617 0.91 SLC7A5 (0.52) SLC7A5SLC1A3SLC1A2ANPEPRNPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023225619-A2 DELIVERY OF FOCAL ADHESION KINASE FOR TREATING VASCULAR AND/OR CAPILLARY TISSUE INJURY BIOSUPERIOR TECHNOLOGY, INC. (US) 2023-11-23 WO claimed
US-20100286023-A1 Compositions and Methods for Increasing Muscle Mass, Strength, and Functional Performance in the Elderly ENERGY LIGHT LLC 2010-11-11 US claimed
US-7790688-B2 Compositions and methods for increasing muscle mass, strength, and functional performance in the elderly HEALTHSPAN SOLUTIONS, LLC (US) 2010-09-07 US claimed
WO-2023225619-A2 DELIVERY OF FOCAL ADHESION KINASE FOR TREATING VASCULAR AND/OR CAPILLARY TISSUE INJURY BIOSUPERIOR TECHNOLOGY, INC. (US) 2023-11-23 WO disclosed
CN-114989250-B Angiotensin converting enzyme inhibitory polypeptide from seawater pearl and application thereof 浙江清荣生物科技发展有限公司 2023-08-15 CN disclosed
CN-115176952-A Preparation method of agrocybe cylindracea fermented radix puerariae and coix seed beverage 贵州大学 2022-10-14 CN disclosed
CN-114752525-B Lactobacillus casei with blood pressure lowering effect and application thereof 广西壮族自治区水牛研究所 2022-09-09 CN disclosed
CN-114989250-A Angiotensin converting enzyme inhibitory polypeptide derived from seawater pearl and application thereof 浙江清荣生物科技发展有限公司 2022-09-02 CN disclosed
CN-114752525-A Lactobacillus casei with blood pressure lowering effect and application thereof 广西壮族自治区水牛研究所 2022-07-15 CN disclosed
CN-109942447-A A kind of amino acid-extraction 罗江晨明生物制品有限公司 2019-06-28 CN disclosed
CN-108271372-A IL-8-BINDING ANTIBODIES AND USES THEREOF 中外制药株式会社 2018-07-10 CN disclosed
CN-101171024-A Blood pressure lowering protein hydrolysates DSM IP ASSETS BV (NL) 2008-04-30 CN disclosed
US-20070128192-A1 Human antibody molecules for il-13 CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED (GB) 2007-06-07 US disclosed
CN-1893838-A Peptides having an ace inhibiting effect UNILEVER NV (NL) 2007-01-10 CN disclosed
EP-1646656-A2 HUMAN ANTIBODY MOLECULES FOR IL-13 CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED (GB) 2006-04-19 EP disclosed
US-6905818-B1 Method for the identification and characterization of interacting molecules by automated interaction mating MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNGDER WISSENSCHAFTEN (DE) 2005-06-14 US disclosed
US-20050065327-A1 Human antibody molecules for IL-13 MEDIMMUNE LIMITED (GB) 2005-03-24 US disclosed
WO-2005007699-A2 HUMAN ANTIBODY MOLECULES FOR IL-13 CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED (GB) 2005-01-27 WO disclosed
WO-1997039132-A9 STABILIZED PREPARATIONS OF HUMAN TROPONINS AND MODIFICATIONS THEREOF, DIAGNOSTIC ASSAY METHODS AND ASSAY KITS 1997-12-24 WO disclosed
WO-1997039132-A1 STABILIZED PREPARATIONS OF HUMAN TROPONINS AND MODIFICATIONS THEREOF, DIAGNOSTIC ASSAY METHODS AND ASSAY KITS UNIVERSITY OF MIAMI (US) 1997-10-23 WO disclosed