Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374091 | 0.82 | POLB (0.58) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL19707851 | 0.74 | KMT2A (0.45) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL4488511 | 0.74 | MIF (0.50) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7227231 | 0.72 | POLB (0.53) | POLBMEN1KMT2AMAPTNPC1 | |
| SCHEMBL19707314 | 0.72 | POLB (0.54) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL11249289 | 0.72 | PDK1 (0.60) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7424794 | 0.72 | PDK1 (0.60) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL4742572 | 0.69 | MEN1 (0.55) | POLBMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL11461831 | 0.69 | SMN1; SMN2 (0.68) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL23137177 | 0.68 | PPARG (0.50) | POLBMEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1678321-A | Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds | RIGEL PHARMACEUTICALS INC (US) | 2005-10-05 | — | — | CN | disclosed |