Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | NEK2 | P51955 | 1/20 | 0.64 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | F2 | P00734 | 3/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | EDNRA | P25101 | 5/20 | 0.49 |
| ▸ | NSD2 | O96028 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10344364 | 0.88 | CA2 (0.60) | CA2CHEK1NEK2LIMK1DYRK1A | |
| SCHEMBL18669851 | 0.84 | CA2 (0.63) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL11127453 | 0.81 | CA2 (0.64) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL28977923 | 0.80 | CA2 (0.62) | CA2CHEK1NEK2LIMK1DYRK1A | |
| SCHEMBL29921971 | 0.79 | CHEK1 (1.00) | CA2CHEK1NEK2LIMK1DYRK1A | |
| SCHEMBL4078292 | 0.79 | CHEK1 (1.00) | CA2CHEK1NEK2LIMK1DYRK1A | |
| SCHEMBL108421 | 0.78 | CA2 (1.00) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL8522841 | 0.78 | CA2 (0.55) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29550086 | 0.78 | CA2 (0.55) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL17294738 | 0.78 | CA2 (0.55) | CA2F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100356923-C | Use of s-10 hydroxy-10, 11-dihydro-carbamazepine for the treatment of anxiety and bipolar disorders | NOVARTIS AG (CH) | 2007-12-26 | — | — | CN | disclosed |
| CN-101062932-A | Enantioselective process for the preparation of both enantiomers of 10,11-dihydro-10-hydroxy-5h-dibenz [b,f]azepine-5-carboxamide and new crystal forms thereof | NOVARTIS AG (CH) | 2007-10-31 | — | — | CN | disclosed |
| CN-1933819-A | Oral matrix formulations comprising licarbazepine | NOVARTIS AG (CH) | 2007-03-21 | — | — | CN | disclosed |
| CN-1933817-A | Disintegrating tablets comprising licarbazepine | NOVARTIS AG (CH) | 2007-03-21 | — | — | CN | disclosed |
| CN-1767834-A | Use of 10-hydroxy-10, 11-dihydrocarbamazepine derivatives for the treatment of affective disorders | NOVARTIS AG (CH) | 2006-05-03 | — | — | CN | disclosed |
| CN-1750826-A | Use of R-10-hydroxy-10, 11-dihydro-carbamazepine in neuropathic pain | NOVARTIS AG (CH) | 2006-03-22 | — | — | CN | disclosed |
| CN-1747735-A | Use of S-10-hydroxy-10, 11-dihydro-carbamazepine for the treatment of anxiety and bipolar disorders | NOVARTIS AG (CH) | 2006-03-15 | — | — | CN | disclosed |
| CN-1703404-A | Enantioselective process for preparing two enantiomers of 10, 11-dihydro-10-hydroxy-5H-dibenzo (b, f) azepine * -5-carboxamide and novel crystalline forms thereof | NOVARTIS AG (CH) | 2005-11-30 | — | — | CN | disclosed |
| CN-1674909-A | Use of carboxamides for the treatment of tinnitus | NOVARTIS AG (CH) | 2005-09-28 | — | — | CN | disclosed |