Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.42 |
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 7/20 | 0.42 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219433 | 0.84 | HTR1A (0.47) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL28753730 | 0.79 | DRD2 (0.49) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL6221472 | 0.79 | DRD2 (0.44) | HTR1ADRD2HTR2AHTR2CADRA1D | |
| SCHEMBL6218716 | 0.78 | HTR1A (0.47) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL6219855 | 0.77 | HTR2A (0.51) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL9778374 | 0.76 | ABCB1 (0.60) | HTR1ADRD2HTR2AHTR2CPARP1 | |
| SCHEMBL27613982 | 0.75 | HTR1A (0.42) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL6745366 | 0.75 | PARP1 (0.42) | HTR1ADRD2HTR2ADRD1HTR2C | |
| SCHEMBL6219902 | 0.74 | PARP1 (0.44) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL6218530 | 0.74 | HTR2A (0.51) | HTR1ADRD2HTR2AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1701072-A | Heterocyclic substituted piperazines for the treatment of schizophrenia | WARNER LAMBERT CO (US) | 2005-11-23 | — | — | CN | disclosed |