Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 16/20 | 0.72 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.72 |
| ▸ | DRD5 | P21918 | 1/20 | 0.72 |
| ▸ | HTR1D | P28221 | 1/20 | 0.72 |
| ▸ | HTR1E | P28566 | 1/20 | 0.72 |
| ▸ | HTR7 | P34969 | 1/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.72 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30730002 | 0.89 | HTR1F (0.85) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL2537137 | 0.89 | HTR1F (0.85) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL30909255 | 0.88 | HTR1F (0.74) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL2537605 | 0.88 | HTR1F (0.74) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL2537931 | 0.88 | HTR1F (0.77) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL30908910 | 0.88 | HTR1F (0.77) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL30908824 | 0.88 | HTR1F (0.74) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL2537908 | 0.88 | HTR1F (0.74) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL2535191 | 0.88 | HTR1F (0.66) | HTR1FCHRM5DRD5HTR1DHTR1E | |
| SCHEMBL2535869 | 0.88 | HTR1F (0.66) | HTR1FCHRM5DRD5HTR1DHTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753171-A | Compositions of 2,4, 6-trifluoro-N- [6- (1-methyl-piperidine-4-carbonyl) -pyridin-2-yl ] -benzamide | COLUCID PHARMACEUTICALS INC | 2012-10-24 | — | — | CN | claimed |
| CN-102753171-A | Compositions of 2,4, 6-trifluoro-N- [6- (1-methyl-piperidine-4-carbonyl) -pyridin-2-yl ] -benzamide | COLUCID PHARMACEUTICALS INC | 2012-10-24 | — | — | CN | disclosed |
| CN-100352817-C | Pyridinoylpiperidines as 5-HTLF agonists | LILLY CO ELI (US) | 2007-12-05 | — | — | CN | disclosed |
| CN-1642939-A | As 5-HT1FPyridylpiperidines as agonists | LILLY CO ELI (US) | 2005-07-20 | — | — | CN | disclosed |