Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21722722 | 0.84 | POLB (0.67) | KMT2AMAPTPOLBKDM4ETDP1 | |
| SCHEMBL5509020 | 0.83 | TSHR (0.67) | KMT2AMAPTPOLBKDM4ETDP1 | |
| SCHEMBL29651934 | 0.83 | TSHR (0.67) | KMT2AMAPTPOLBKDM4ETDP1 | |
| SCHEMBL10421022 | 0.80 | MAPT (0.63) | KMT2AMAPTPOLBKDM4ETDP1 | |
| SCHEMBL27634865 | 0.80 | MAPT (0.63) | KMT2AMAPTPOLBKDM4ETDP1 | |
| SCHEMBL8705860 | 0.79 | MAPT (0.63) | KMT2AMAPTPOLBKDM4ETDP1 | |
| SCHEMBL27836775 | 0.79 | POLB (0.60) | KMT2AMAPTPOLBKDM4ETDP1 | |
| SCHEMBL29214342 | 0.77 | HTT (0.49) | KMT2AMAPTPOLBKDM4ETDP1 | |
| SCHEMBL10722877 | 0.75 | CYP1A2 (0.53) | KMT2AMAPTPOLBKDM4ETSHR | |
| SCHEMBL11267709 | 0.75 | KDM4E (0.67) | KMT2AMAPTKDM4ETDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809554-A | 3-substituted 5,6-diaryl-pyrazine-2-carboxamide and -2-sulfonamide derivatives as cb1 modulators | ASTRAZENECA AB (SE) | 2006-07-26 | — | — | CN | disclosed |
| CN-1620438-A | 5, 6-diaryl-pyrazine-2-amide derivatives as CBI antagonists | ASTRAZENECA AB (SE) | 2005-05-25 | — | — | CN | disclosed |