Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | MC4R | P32245 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | MC3R | P41968 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615063 | 0.80 | KMT2A (0.68) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL21722722 | 0.80 | POLB (0.67) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL29651934 | 0.80 | TSHR (0.67) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL5509020 | 0.80 | TSHR (0.67) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL28038911 | 0.79 | P2RX7 (0.47) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL10421022 | 0.77 | MAPT (0.63) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL8705860 | 0.75 | MAPT (0.63) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL27836775 | 0.75 | POLB (0.60) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL21722578 | 0.72 | POLB (0.53) | MAPTKDM4ETDP1POLBKMT2A | |
| SCHEMBL26136818 | 0.71 | F2 (0.45) | MAPTKMT2AHSD17B10F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1809554-A | 3-substituted 5,6-diaryl-pyrazine-2-carboxamide and -2-sulfonamide derivatives as cb1 modulators | ASTRAZENECA AB (SE) | 2006-07-26 | — | — | CN | disclosed |