Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615896 | 0.92 | POLB (0.43) | POLBCDK8RAB9AWNT3AALDH1A1 | |
| SCHEMBL27597124 | 0.90 | POLB (0.41) | POLBCDK8RAB9AWNT3AALDH1A1 | |
| SCHEMBL27615895 | 0.90 | POLB (0.41) | POLBCDK8RAB9AWNT3AALDH1A1 | |
| SCHEMBL5557258 | 0.89 | CDK8 (0.39) | POLBCDK8WNT3A | |
| SCHEMBL27615930 | 0.89 | POLB (0.42) | POLBCDK8RAB9AWNT3AALDH1A1 | |
| SCHEMBL28754186 | 0.89 | POLB (0.40) | POLBCDK8RAB9AWNT3A | |
| SCHEMBL28751517 | 0.88 | POLB (0.44) | POLBCDK8RAB9AWNT3AALDH1A1 | |
| SCHEMBL27597121 | 0.87 | POLB (0.46) | POLBRAB9AWNT3A | |
| SCHEMBL27597155 | 0.87 | POLB (0.46) | POLBRAB9AWNT3A | |
| SCHEMBL27597128 | 0.86 | ALDH1A1 (0.50) | POLBRAB9AALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497333-C | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| CN-1633430-A | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2005-06-29 | — | — | CN | disclosed |