Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 5/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | WNT3A | P56704 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615925 | 0.92 | POLB (0.39) | POLBCCR2KCNH2WNT3APTGES | |
| SCHEMBL5556303 | 0.90 | AAK1 (0.36) | POLBCDK8CCR2KCNH2WNT3A | |
| SCHEMBL27597135 | 0.89 | IDO1 (0.41) | POLBWNT3AIDO1RAB9A | |
| SCHEMBL27615857 | 0.89 | POLB (0.41) | POLBWNT3ARAB9A | |
| SCHEMBL27615902 | 0.89 | POLB (0.45) | POLBCDK8WNT3ARAB9A | |
| SCHEMBL27597169 | 0.88 | POLB (0.36) | POLBCCR2KCNH2WNT3APTGES | |
| SCHEMBL5556936 | 0.87 | DGAT1 (0.40) | POLBCCR2KCNH2WNT3AIDO1 | |
| SCHEMBL27597142 | 0.87 | POLB (0.41) | POLBCDK8WNT3ARAB9A | |
| SCHEMBL27615982 | 0.87 | MEN1 (0.46) | POLBCCR2KCNH2IDO1 | |
| SCHEMBL27615862 | 0.87 | RAB9A (0.39) | POLBWNT3APTGESIDO1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497333-C | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| CN-1633430-A | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2005-06-29 | — | — | CN | disclosed |