Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | CCR2 | P41597 | 3/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615833 | 0.89 | ALDH1A1 (0.46) | MEN1ALDH1A1KMT2AKCNH2CCR2 | |
| SCHEMBL5556798 | 0.89 | MEN1 (0.40) | MEN1ALDH1A1KMT2AKCNH2CCR2 | |
| SCHEMBL27597180 | 0.87 | ABL1 (0.42) | — | |
| SCHEMBL27597157 | 0.87 | MEN1 (0.43) | MEN1ALDH1A1KMT2AKCNH2CCR2 | |
| SCHEMBL27597128 | 0.87 | ALDH1A1 (0.50) | MEN1ALDH1A1KMT2ASLC1A3SLC1A2 | |
| SCHEMBL28754186 | 0.87 | POLB (0.40) | KCNH2CCR2POLBIDO1 | |
| SCHEMBL27615925 | 0.86 | POLB (0.39) | KCNH2CCR2SYKPOLBIDO1 | |
| SCHEMBL27615928 | 0.85 | ALDH1A1 (0.45) | MEN1ALDH1A1KMT2AKCNH2CCR2 | |
| SCHEMBL27615852 | 0.85 | MEN1 (0.48) | MEN1ALDH1A1KMT2ASLC1A3SLC1A2 | |
| SCHEMBL27597107 | 0.83 | MEN1 (0.46) | MEN1ALDH1A1KMT2ASLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100497333-C | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |
| CN-1633430-A | Dihydrobenzodiazepin-2-one derivatives for the treatment of neurological disorders | HOFFMANN LA ROCHE (CH) | 2005-06-29 | — | — | CN | disclosed |