Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.47 |
| ▸ | PARP15 | Q460N3 | 5/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2494139 | 0.74 | MAOB (0.57) | MAOAMAOBHPGDALDH1A1 | |
| SCHEMBL31217566 | 0.74 | PPIB (0.54) | HPGDKDM4EALDH1A1GLAGAA | |
| SCHEMBL2761874 | 0.71 | PDK2 (0.43) | MAOAMAOBPDK2HPGDGRM2 | |
| SCHEMBL2761768 | 0.71 | TLK2 (0.41) | BRD4HPGDKDM4EALDH1A1GLA | |
| SCHEMBL31580938 | 0.70 | MAOB (0.61) | MAOAMAOBPARP10PARP15 | |
| SCHEMBL20554464 | 0.69 | MAOB (0.61) | MAOAMAOBPARP10PARP15HPGD | |
| SCHEMBL30132700 | 0.69 | MAOB (0.61) | MAOAMAOBPARP10PARP15HPGD | |
| SCHEMBL10249569 | 0.67 | MAOA (0.61) | MAOAMAOBBRD4PARP10PARP15 | |
| SCHEMBL22168428 | 0.67 | SLC6A2 (0.71) | MAOAMAOBPARP10PARP15PDK2 | |
| SCHEMBL10267513 | 0.67 | PARP10 (0.54) | MAOAMAOBPARP10PARP15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324405-B2 | Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors | FIBROGEN, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100331400-A1 | CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS | FIBROGEN, INC. | 2010-12-30 | — | — | US | disclosed |
| WO-2009100250-A1 | CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS | FIBROGEN, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331400-A1 | CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS | HIF1AN, HIF1A, EGLN2 | MAOA 321/4885MAOB 424/4885BRD4 2439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.