Sugi Predict

Sugi Predict / Compounds / SCHEMBL2761689

SCHEMBL2761689

SCHEMBL2761689

CC(NC(=O)c1c(O)c2ccc(OC3CCCCC3)cc2oc1=O)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 8/20 0.48
▸ MAOA P21397 6/20 0.44
▸ PTGS1 P23219 1/20 0.43
▸ PTGS2 P35354 1/20 0.43
▸ KDM4E B2RXH2 5/20 0.40
▸ ALDH1A1 P00352 5/20 0.40
▸ HSD17B10 Q99714 4/20 0.40
▸ HPGD P15428 4/20 0.40
▸ TSHR P16473 2/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39
▸ NQO1 P15559 1/20 0.38
▸ MTHFD1 P11586 1/20 0.38
▸ MTHFD2 P13995 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ TP53 P04637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2761690 1.00 MAOB (0.48) MAOBMAOAPTGS1PTGS2KDM4E
SCHEMBL2761791 0.83 MAOB (0.52) MAOBMAOAKDM4EALDH1A1HSD17B10
SCHEMBL2762089 0.82 MAOB (0.50) MAOBMAOAKDM4EALDH1A1MEN1
SCHEMBL2761975 0.80 PDE4A (0.38) MAOBALDH1A1MEN1KMT2ARAB9A
SCHEMBL2761976 0.80 PDE4A (0.38) MAOBALDH1A1MEN1KMT2ARAB9A
SCHEMBL2762083 0.79 LMNA (0.42) MAOBMAOAKDM4EALDH1A1HPGD
SCHEMBL2762082 0.79 LMNA (0.42) MAOBMAOAKDM4EALDH1A1HPGD
SCHEMBL2761411 0.78 MAOA (0.56) MAOBMAOAKDM4EALDH1A1MEN1
SCHEMBL2761412 0.78 MAOA (0.56) MAOBMAOAKDM4EALDH1A1MEN1
SCHEMBL2761787 0.77 KDM4C (0.44) ALDH1A1KMT2ANQO1ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8324405-B2 Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors FIBROGEN, INC. (US) 2012-12-04 — — US claimed
US-20100331400-A1 CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS FIBROGEN, INC. 2010-12-30 — — US claimed
WO-2009100250-A1 CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS FIBROGEN, INC. (US) 2009-08-13 — — WO claimed
US-8324405-B2 Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors FIBROGEN, INC. (US) 2012-12-04 — — US disclosed
US-20100331400-A1 CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS FIBROGEN, INC. 2010-12-30 — — US disclosed
WO-2009100250-A1 CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS FIBROGEN, INC. (US) 2009-08-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100331400-A1 CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS HIF1AN, HIF1A, EGLN2 MAOB 424/4885MAOA 321/4885PTGS1 208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.