Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 4/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240697 | 0.81 | SIGMAR1 (0.37) | — | |
| SCHEMBL2523971 | 0.81 | NOTUM (0.47) | CLK4MCHR1XDHSLC22A12NOTUM | |
| SCHEMBL2523974 | 0.81 | NOTUM (0.47) | CLK4MCHR1XDHSLC22A12NOTUM | |
| SCHEMBL27803799 | 0.77 | CLK4 (0.50) | CLK4MAOBPGRXDHSLC22A12 | |
| SCHEMBL27617600 | 0.77 | IDO1 (0.35) | KMT2AIDO1TSHR | |
| SCHEMBL2521850 | 0.77 | MCHR1 (0.41) | MCHR1XDHSLC22A12KMT2AIDO1 | |
| SCHEMBL2521851 | 0.77 | MCHR1 (0.41) | MCHR1XDHSLC22A12KMT2AIDO1 | |
| SCHEMBL27599030 | 0.74 | CREBBP (0.41) | CLK4MAOBSLC6A2SLC6A3PGR | |
| SCHEMBL2511131 | 0.74 | CNR2 (0.44) | MCHR1TSHR | |
| SCHEMBL2511133 | 0.74 | CNR2 (0.44) | MCHR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1617718-A | N-aryl-N'-arylcycloalkyl-urea derivatives as MCH antagonists for the treatment of obesity | SCHERING CORP (US) | 2005-05-18 | — | — | CN | disclosed |