Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR4 | P46093 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947385 | 0.87 | GPR4 (0.43) | GPR4 | |
| SCHEMBL1625428 | 0.86 | GPR4 (0.35) | GPR4 | |
| SCHEMBL1625470 | 0.86 | GPR4 (0.35) | GPR4 | |
| SCHEMBL1624690 | 0.86 | GPR4 (0.35) | GPR4 | |
| SCHEMBL27579860 | 0.83 | GPR4 (0.45) | GPR4 | |
| SCHEMBL27600077 | 0.82 | — | — | |
| SCHEMBL28008299 | 0.81 | GPR4 (0.32) | GPR4 | |
| SCHEMBL3949488 | 0.80 | AKT1 (0.35) | — | |
| SCHEMBL1624681 | 0.79 | AGTR1 (0.37) | — | |
| SCHEMBL3947731 | 0.78 | GPR4 (0.34) | GPR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100579518-C | Use of EP4 receptor ligands for the manufacture of a medicament for the treatment of IL-6 related disorders | PFIZER | 2010-01-13 | — | — | CN | disclosed |
| CN-101023946-A | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases | PFIZER (US) | 2007-08-29 | — | — | CN | disclosed |
| CN-1658847-A | Use of EP4 receptor ligands for the treatment of IL-6 related disorders | PFIZER (US) | 2005-08-24 | — | — | CN | disclosed |