Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCTPP1 | Q9H773 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27618420 | 0.82 | KMT2A (0.45) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL7100254 | 0.81 | PDE10A (0.34) | KMT2A | |
| SCHEMBL6425324 | 0.80 | NR1H2 (0.35) | ALDH1A1LMNAMAPTCA12CA9 | |
| SCHEMBL27600064 | 0.79 | PDE10A (0.32) | — | |
| SCHEMBL5772661 | 0.79 | PPARG (0.36) | KMT2ACA12CA9SMN1; SMN2 | |
| SCHEMBL7097335 | 0.79 | NR1H2 (0.37) | — | |
| SCHEMBL27618382 | 0.78 | PDE10A (0.38) | DCTPP1ALDH1A1 | |
| SCHEMBL1623967 | 0.78 | PGK1 (0.40) | DCTPP1ALDH1A1PGK1MEN1KMT2A | |
| SCHEMBL27582732 | 0.78 | CYP1A2 (0.41) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL27600071 | 0.78 | PDE10A (0.40) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100579518-C | Use of EP4 receptor ligands for the manufacture of a medicament for the treatment of IL-6 related disorders | PFIZER | 2010-01-13 | — | — | CN | disclosed |
| CN-101023946-A | Use of EP4 receptor ligands in the treatment of IL-6 involved diseases | PFIZER (US) | 2007-08-29 | — | — | CN | disclosed |
| CN-1658847-A | Use of EP4 receptor ligands for the treatment of IL-6 related disorders | PFIZER (US) | 2005-08-24 | — | — | CN | disclosed |