Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27600064 | 0.87 | PDE10A (0.32) | PDE10ACYP1A2ESR1ESR2 | |
| SCHEMBL7097335 | 0.82 | NR1H2 (0.37) | PDE10ACYP1A2RAB9A | |
| SCHEMBL27618382 | 0.82 | PDE10A (0.38) | PDE10ACYP1A2ESR1ESR2KDM4E | |
| SCHEMBL6425324 | 0.81 | NR1H2 (0.35) | PDE10ACYP1A2ESR1ESR2 | |
| SCHEMBL27600071 | 0.81 | PDE10A (0.40) | PDE10ACYP1A2KMT2AKDM4E | |
| SCHEMBL27582732 | 0.81 | CYP1A2 (0.41) | PDE10ACYP1A2KMT2AKDM4ERAB9A | |
| SCHEMBL5772661 | 0.81 | PPARG (0.36) | PDE10ACYP1A2KMT2ANPSR1ESR1 | |
| SCHEMBL27618366 | 0.81 | DCTPP1 (0.40) | KMT2A | |
| SCHEMBL27599854 | 0.79 | ALDH1A1 (0.51) | PDE10ACYP1A2KDM4E | |
| SCHEMBL6899886 | 0.78 | PTGDR2 (0.32) | PDE10ACYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |