Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27637814 | 0.88 | MEN1 (0.45) | MEN1KMT2AKCNH2LMNAKCNA5 | |
| SCHEMBL27618696 | 0.88 | MEN1 (0.45) | MEN1KMT2AKCNH2LMNAKCNA5 | |
| SCHEMBL6514089 | 0.84 | KCNH2 (0.44) | MEN1KMT2AKCNH2LMNAKCNA5 | |
| SCHEMBL1762977 | 0.80 | CYP2C9 (0.49) | KMT2AKCNH2SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL27637811 | 0.75 | LMNA (0.52) | MEN1KMT2AKCNH2LMNAKCNA5 | |
| SCHEMBL1763655 | 0.69 | CYP2C19 (0.51) | KMT2AKCNH2LMNAKDM4EALDH1A1 | |
| SCHEMBL30122294 | 0.69 | CYP2D6 (0.56) | MEN1KMT2AKCNH2LMNAKCNA5 | |
| SCHEMBL28168044 | 0.69 | CYP2C9 (0.68) | MEN1KMT2AKCNH2LMNAKCNA5 | |
| SCHEMBL1763425 | 0.69 | CYP3A4 (0.60) | KMT2AKCNH2SIGMAR1ALDH1A1 | |
| SCHEMBL2080255 | 0.68 | CYP3A4 (0.55) | KMT2AKCNH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101229164-B | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives | BRISTOL MYERS SQUIBB CO | 2013-01-02 | — | — | CN | disclosed |
| CN-101229164-A | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2008-07-30 | — | — | CN | disclosed |
| CN-100379421-C | Compositions and antiviral activity of substituted azaindoloxoacetylpiperazine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2008-04-09 | — | — | CN | disclosed |
| CN-1688311-A | Compositions and antiviral activity of substituted azaindoloxoacetylpiperazine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2005-10-26 | — | — | CN | disclosed |