Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | MELK | Q14680 | 3/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.30 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619679 | 0.66 | SRC (0.49) | LSSHRH3MELKTAAR1SRC | |
| SCHEMBL27686135 | 0.65 | HRH3 (0.37) | LSSHRH3TLR7TAAR1NTRK1 | |
| SCHEMBL156261 | 0.64 | CYP2A6 (0.58) | LSSHRH3TAAR1ROCK2 | |
| Hydrochloric Acid SCHEMBL28582005 | 0.63 | CYP2A6 (0.56) | LSSHRH3TAAR1ROCK2 | |
| SCHEMBL10924184 | 0.60 | LSS (0.57) | LSSHRH3TAAR1ROCK2 | |
| SCHEMBL12679031 | 0.58 | HRH3 (1.00) | HRH3TAAR1BRD4BRD9TTK | |
| SCHEMBL28754797 | 0.58 | SRC (0.49) | MELKSRCPRKCQPRKCD | |
| SCHEMBL10928213 | 0.58 | MAOB (0.62) | HRH3 | |
| SCHEMBL10925683 | 0.57 | SNCA (0.50) | LSSHRH3TAAR1ROCK2 | |
| SCHEMBL10925686 | 0.57 | SNCA (0.50) | LSSHRH3TAAR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1714092-A | Thieno [3, 2-b ] pyridine-6-carbonitriles and thieno [2, 3-b ] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH CORP (US) | 2005-12-28 | — | — | CN | claimed |
| CN-1714092-A | Thieno [3, 2-b ] pyridine-6-carbonitriles and thieno [2, 3-b ] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH CORP (US) | 2005-12-28 | — | — | CN | disclosed |