Acetic Acid

Acetic Acid

SCHEMBL2761986

CC(=O)[O-].CC[N+](C)(C)CCOC

nearest known ligand 0.48

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB4 known ✓ P30926 1/20 0.34
CHRNA3 known ✓ P32297 1/20 0.34
ADRA2A known ✓ P08913 1/20 0.30
BBOX1 O75936 4/20 0.48
CHRM5 P08912 2/20 0.34
CHRM1 P11229 2/20 0.34
CHRM3 P20309 2/20 0.34
PGR P06401 1/20 0.34
CHRM2 P08172 1/20 0.34
CHRM4 P08173 1/20 0.34
HTR1A P08908 1/20 0.34
CHRNB2 P17787 1/20 0.34
TBXA2R P21731 1/20 0.34
CHRNA7 P36544 1/20 0.34
CHRNA4 P43681 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CHRNA10 Q9GZZ6 1/20 0.34
CHRNA9 Q9UGM1 1/20 0.34
GALR3 O60755 2/20 0.34
CA1 P00915 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propionic Acid SCHEMBL142732 0.90 BBOX1 (0.52) BBOX1DNM1HTTKMT2AHSP90AA1
Butyric Acid SCHEMBL143567 0.85 BBOX1 (0.56) BBOX1CA1
SCHEMBL119566 0.84
Acetic Acid SCHEMBL14801758 0.83 BBOX1 (0.48) BBOX1CHRM5CHRM1CHRM3PGR
Bicarbonate SCHEMBL718083 0.82 BBOX1 (0.35) BBOX1CHRM5CHRM1CHRM3PGR
Valeric Acid SCHEMBL145773 0.82 BBOX1 (0.62) BBOX1CA1DNM1HTTKMT2A
Water SCHEMBL142997 0.82 DNM1 (0.40) BBOX1CHRNB4CHRNA3CHRNA7DNM1
Bromide SCHEMBL145264 0.82 DNM1 (0.44) BBOX1CHRNB4CHRNA3CHRNA7DNM1
Hydrochloric Acid SCHEMBL16594014 0.82 DNM1 (0.40) BBOX1CHRNB4CHRNA3CHRNA7DNM1
Iodide SCHEMBL2430929 0.82 DNM1 (0.40) BBOX1CHRNB4CHRNA3CHRNA7DNM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010136105-A2 AMMONIUMCARBOXYLATES MERCK PATENT GMBH (DE) 2010-12-02 WO claimed
WO-2010136105-A2 AMMONIUMCARBOXYLATES MERCK PATENT GMBH (DE) 2010-12-02 WO disclosed