Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 10/20 | 0.51 |
| ▸ | CA2 | P00918 | 10/20 | 0.51 |
| ▸ | CA1 | P00915 | 8/20 | 0.51 |
| ▸ | CA12 | O43570 | 5/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CCR1 | P32246 | 2/20 | 0.50 |
| ▸ | CCR5 | P51681 | 2/20 | 0.50 |
| ▸ | CCR8 | P51685 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8438728 | 0.84 | P4HTM (0.56) | P4HTMKDM4ELMNACCR1CCR5 | |
| SCHEMBL29774732 | 0.84 | P4HTM (0.56) | P4HTMKDM4ELMNACCR1CCR5 | |
| Dipyridyl SCHEMBL28775778 | 0.83 | CA9 (0.64) | CA9CA2CA1CA12P4HTM | |
| SCHEMBL28004660 | 0.82 | PTGS2 (0.51) | P4HTMKDM4ELMNACCR1CCR5 | |
| SCHEMBL8808963 | 0.82 | KDM4E (0.50) | CA9CA2CA1CA12P4HTM | |
| SCHEMBL8803751 | 0.80 | CA9 (0.69) | CA9CA2CA1CA12PTGS1 | |
| SCHEMBL18191710 | 0.80 | CA1 (0.57) | CA9CA2CA1CA12HTT | |
| Dipyridyl SCHEMBL27645628 | 0.77 | KDM4E (0.64) | CA9CA2CA1CA12P4HTM | |
| SCHEMBL30846393 | 0.76 | CA9 (0.68) | CA9CA2CA1CA12LMNA | |
| SCHEMBL14377939 | 0.75 | CA2 (0.52) | CA9CA2CA1CA12PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010092015-A1 | UREA TRIAZOLOLO [1, 5-A] PYRIDINE DERIVATIVES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |