Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375808 | 0.85 | GAA (0.65) | GAAALDH1A1SMN1; SMN2L3MBTL1HSP90AA1 | |
| SCHEMBL27786432 | 0.83 | CA12 (0.55) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL27622139 | 0.82 | MAPT (0.44) | GAAALDH1A1SMN1; SMN2HSP90AA1LMNA | |
| SCHEMBL27853349 | 0.81 | RXFP1 (0.65) | ALDH1A1SMN1; SMN2L3MBTL1LMNAHTT | |
| SCHEMBL10126443 | 0.80 | GAA (0.76) | GAAALDH1A1SMN1; SMN2L3MBTL1HSP90AA1 | |
| SCHEMBL27939943 | 0.79 | ALDH1A1 (0.57) | GAAALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL2378269 | 0.78 | GAA (0.69) | GAAALDH1A1SMN1; SMN2L3MBTL1HSP90AA1 | |
| SCHEMBL29601441 | 0.78 | GAA (0.72) | GAAALDH1A1SMN1; SMN2L3MBTL1HSP90AA1 | |
| SCHEMBL22767195 | 0.78 | GAA (1.00) | GAAALDH1A1SMN1; SMN2L3MBTL1HSP90AA1 | |
| SCHEMBL27839255 | 0.75 | HPGD (0.59) | ALDH1A1L3MBTL1LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101921236-B | 2, 4- di (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG | 2013-01-16 | — | — | CN | disclosed |
| CN-101921236-A | Can be used for treating 2 of neoplastic disease, inflammatory and disorder of immune system, 4-two (phenylamino) pyrimidine | NOVARTIS AG | 2010-12-22 | — | — | CN | disclosed |
| CN-1788001-B | 2, 4-bis (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG | 2010-09-22 | — | — | CN | disclosed |
| CN-1788001-A | 2, 4-bis (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2006-06-14 | — | — | CN | disclosed |