Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 1/20 | 0.57 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.57 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21082065 | 0.85 | HDAC1 (0.54) | HDAC1HDAC6SMN1; SMN2MAPK1THRB | |
| SCHEMBL20916923 | 0.81 | HDAC1 (0.57) | PLOD2PLOD3PLOD1HDAC1HDAC6 | |
| SCHEMBL4263053 | 0.78 | HDAC1 (0.53) | PLOD2PLOD3PLOD1HDAC1HDAC6 | |
| SCHEMBL15012492 | 0.77 | THRB (0.60) | PLOD2PLOD3PLOD1HDAC1HDAC6 | |
| SCHEMBL4718567 | 0.76 | ALDH1A1 (0.57) | PLOD2PLOD3PLOD1HDAC1HDAC6 | |
| SCHEMBL27889580 | 0.76 | HDAC1 (0.54) | PLOD2HDAC1HDAC6THRBLMNA | |
| SCHEMBL21082071 | 0.76 | HDAC1 (0.54) | HDAC1HDAC6SMN1; SMN2MAPK1THRB | |
| SCHEMBL628398 | 0.76 | HDAC1 (0.62) | PLOD2PLOD3PLOD1HDAC1HDAC6 | |
| SCHEMBL4731567 | 0.76 | ALDH1A1 (0.66) | HDAC1HDAC6SMN1; SMN2THRBLMNA | |
| Nicoxamat SCHEMBL29824802 | 0.75 | HDAC1 (0.77) | PLOD2PLOD3PLOD1HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110300754-A | Pyrrolo [1,2-b ] pyridazine derivatives | 吉利德科学公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-105263497-B | Use of substituted 2, 3-dihydroimidazo [1,2-c ] quinazolines for the treatment of lymphomas | 拜耳制药股份公司 | 2019-04-30 | — | — | CN | disclosed |
| CN-108774232-A | 2,3- glyoxalidine simultaneously [1,2-c] quinazoline substitutive derivative | 拜耳知识产权有限责任公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-105339368-B | Imidazo [1,2 a] pyridine of 3 aryl substitution and application thereof | 拜耳制药股份公司 | 2017-08-15 | — | — | CN | disclosed |
| CN-103608018-B | Use of substituted 2, 3-dihydroimidazo [1,2-C ] quinazolines | 拜耳知识产权有限责任公司 | 2017-06-30 | — | — | CN | disclosed |
| CN-105254634-A | SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER PHARMACEUTICALS CORP | 2016-01-20 | — | — | CN | disclosed |
| CN-104364247-A | Carboxamide compounds and their use as calpain inhibitors V | ABBVIE DEUTSCHLAND | 2015-02-18 | — | — | CN | disclosed |
| CN-102159547-A | Heterocyclic carboxamide compounds | ASTELLAS PHARMA INC | 2011-08-17 | — | — | CN | disclosed |
| CN-101600691-A | Acyclic derivatives as modulators of chemokine receptor activity | BRISTOL MYERS SQUIBB CO (US) | 2009-12-09 | — | — | CN | disclosed |
| CN-101475528-A | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-07-08 | — | — | CN | disclosed |
| CN-100475793-C | Quinazoline derivatives and use for preparing medicine | TAISHO PHARMACEUTICAL CO LTD (JP) | 2009-04-08 | — | — | CN | disclosed |
| CN-100469778-C | Novel fused imidazole derivatives | EISAI R&D MAN CO LTD (JP) | 2009-03-18 | — | — | CN | disclosed |
| CN-100451004-C | Pyrimidine derivatives | ARENA PHARM INC (JP) | 2009-01-14 | — | — | CN | disclosed |
| CN-100348599-C | Novel fused imidazole derivatives | EISAI CO LTD (JP) | 2007-11-14 | — | — | CN | disclosed |
| CN-1931859-A | New fused imidazole derivative | EISAI CO LTD (JP) | 2007-03-21 | — | — | CN | disclosed |
| CN-1898239-A | Novel diazaspiroalkanes and their use in the treatment of CCR8 mediated diseases | ASTRAZENECA AB (SE) | 2007-01-17 | — | — | CN | disclosed |
| CN-1798736-A | Novel quinoline, tetrahydroquinazoline and pyrimidine derivatives and methods of treatment related to their use | ARENA PHARM INC (JP) | 2006-07-05 | — | — | CN | disclosed |
| CN-1795180-A | Novel quinazoline derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO LTD (JP) | 2006-06-28 | — | — | CN | disclosed |
| CN-1675208-A | Novel fused imidazole derivatives | EISAI CO LTD (JP) | 2005-09-28 | — | — | CN | disclosed |