Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | KMO | O15229 | 2/20 | 0.52 |
| ▸ | PRKCI | P41743 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207161 | 0.86 | KMO (0.71) | AURKAKMOPRKCINOTUMHDAC8 | |
| SCHEMBL29627221 | 0.86 | KMO (0.71) | AURKAKMOPRKCINOTUMHDAC8 | |
| SCHEMBL17742693 | 0.85 | FYN (0.56) | AURKAKMOPRKCIKIF11 | |
| SCHEMBL31532683 | 0.85 | FYN (0.56) | AURKAKMOPRKCIKIF11 | |
| SCHEMBL30860478 | 0.85 | FYN (0.57) | AURKAKMOPRKCI | |
| SCHEMBL207988 | 0.85 | AURKA (0.50) | AURKAKMOPRKCINOTUMSIRT2 | |
| SCHEMBL1382873 | 0.85 | FYN (0.57) | AURKAKMOPRKCI | |
| SCHEMBL16108896 | 0.83 | KMO (0.56) | MEN1KMT2AAURKAKMOPRKCI | |
| Hydrochloric Acid SCHEMBL30037727 | 0.83 | FYN (0.56) | AURKAKMOPRKCI | |
| SCHEMBL16858233 | 0.83 | KMO (0.72) | MEN1KMT2AKMOATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | claimed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | claimed |
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | disclosed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | disclosed |