Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PTPRS | Q13332 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375593 | 0.87 | S1PR4 (0.57) | S1PR4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL28750265 | 0.86 | S1PR4 (0.56) | S1PR4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL375486 | 0.83 | S1PR4 (0.60) | S1PR4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL499141 | 0.80 | ALDH1A1 (0.53) | S1PR4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL10252888 | 0.73 | NPC1 (0.64) | S1PR4ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL18169219 | 0.73 | ALDH1A1 (0.73) | S1PR4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL5605299 | 0.71 | HPGD (0.48) | S1PR4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL4700249 | 0.71 | CHRNA7 (0.53) | S1PR4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL18876413 | 0.71 | ALDH1A1 (0.46) | S1PR4ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL3348926 | 0.71 | S1PR4 (0.48) | S1PR4ALDH1A1HPGDKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | claimed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | claimed |
| CN-100343256-C | Biaryl substituted diazabicycloalkane amides as nicotinic acetylcholine agonists | ASTRAZENECA AB (SE) | 2007-10-17 | — | — | CN | disclosed |
| CN-1678615-A | Biaryl substituted diazabicycloalkanes as nicotinic acetylcholine antagonists | ASTRAZENECA AB (SE) | 2005-10-05 | — | — | CN | disclosed |