Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | SCN1A | P35498 | 1/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22758114 | 0.89 | MAPT (0.55) | KMT2ALMNAMAPTCHRM3CHRM2 | |
| SCHEMBL9944022 | 0.87 | MEN1 (0.57) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL26134188 | 0.85 | CHRM3 (0.55) | KMT2AMAPTCHRM3CHRM2CHRM1 | |
| SCHEMBL4283827 | 0.84 | CHRM3 (0.53) | KMT2AMAPTCHRM3CHRM2CHRM1 | |
| SCHEMBL959566 | 0.81 | KMT2A (0.57) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL20138486 | 0.78 | KMT2A (0.50) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL5161360 | 0.77 | MAPT (0.46) | KMT2AMAPTSSTR4 | |
| SCHEMBL3951181 | 0.76 | CYP2D6 (0.70) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL10361030 | 0.76 | CYP2D6 (0.51) | KMT2AMEN1LMNACYP2D6HRH1 | |
| SCHEMBL953947 | 0.75 | KMT2A (0.50) | KMT2AMEN1LMNACYP2D6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335369-A | GEM-disubstituted piperidine melanocortin subtype-2 receptor (MC 2R) antagonists and uses thereof | 克林提克斯医药股份有限公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-101048161-A | Arylthiobenzylpiperidine Derivatives | LUNDBECK & CO AS H (DK) | 2007-10-03 | — | — | CN | disclosed |
| CN-1671386-A | Substituted anilinic piperidines as MCH selective antagonists | LUNDBECK & CO AS H (DK) | 2005-09-21 | — | — | CN | disclosed |