Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | SCN1A | P35498 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.57 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4243455 | 0.88 | KEAP1 (0.50) | KMT2ACHRM3KEAP1NFE2L2CHRM2 | |
| SCHEMBL4243228 | 0.88 | KEAP1 (0.50) | KMT2ACHRM3KEAP1NFE2L2CHRM2 | |
| SCHEMBL27749385 | 0.88 | KEAP1 (0.50) | KMT2ACHRM3KEAP1NFE2L2CHRM2 | |
| SCHEMBL27626467 | 0.87 | KMT2A (0.54) | MEN1LMNACYP2D6HRH1SCN1A | |
| SCHEMBL4203042 | 0.84 | KEAP1 (0.61) | CHRM3KEAP1NFE2L2CHRM2CHRM1 | |
| SCHEMBL4213705 | 0.84 | KEAP1 (0.61) | CHRM3KEAP1NFE2L2CHRM2CHRM1 | |
| SCHEMBL4203592 | 0.84 | KEAP1 (0.61) | CHRM3KEAP1NFE2L2CHRM2CHRM1 | |
| SCHEMBL14587261 | 0.84 | KEAP1 (0.56) | LMNAKMT2ACHRM3KEAP1NFE2L2 | |
| SCHEMBL2788610 | 0.83 | KEAP1 (0.59) | CYP2D6CHRM3KEAP1NFE2L2CHRM2 | |
| SCHEMBL19031911 | 0.80 | MEN1 (0.38) | MEN1LMNACYP2D6HRH1SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464632-A1 | PYRIMIDONE DERIVATIVES USED AS TAU PROTEIN KINASE 1 INHIBITORS | Mitsubishi Tanabe Pharma Corporation (JP) | 2012-06-20 | — | — | EP | disclosed |